The Construction of Tissue-Engineered Blood Vessels Crosslinked with Adenosine-Loaded Chitosan/β-Cyclodextrin Nanoparticles using a Layer-by-Layer Assembly Method

A tissue‐engineered blood vessel (TEBV) modified with CS/β‐CD nanoparticles is constructed, effectively controling the release of adenosine, and this type of TEBV can keep open for over 6 months. This study also demonstrates for the first time that adenosine promotes endothelial progenitor cell (EPC...

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Veröffentlicht in:	Advanced healthcare materials 2014-11, Vol.3 (11), p.1776-1781
Hauptverfasser:	Chen, Wen, Zeng, Wen, Wu, Yangxiao, Wen, Can, Li, Li, Liu, Ge, Shen, Lei, Yang, Mingcan, Tan, Ju, Zhu, Chuhong
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine Adenosine - administration & dosage Animals beta-Cyclodextrins - administration & dosage Biological and medical sciences Biotechnology blood vessels Blood Vessels - drug effects Chitosan - administration & dosage Cross-disciplinary physics: materials science rheology Delayed-Action Preparations - administration & dosage endothelial progenitor cells Endothelial Progenitor Cells - drug effects Exact sciences and technology Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects layer-by-layer Materials science Medical sciences Mice Mice, Inbred C57BL Miscellaneous nanoparticles Nanoparticles - administration & dosage Nanoscale materials and structures: fabrication and characterization Physics Rats Rats, Wistar Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments tissue engineering Tissue Engineering - methods
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Zusammenfassung:	A tissue‐engineered blood vessel (TEBV) modified with CS/β‐CD nanoparticles is constructed, effectively controling the release of adenosine, and this type of TEBV can keep open for over 6 months. This study also demonstrates for the first time that adenosine promotes endothelial progenitor cell (EPC) mobilization and homing via energy conversion, achieving rapid endothelialization of TEBV.
ISSN:	2192-2640 2192-2659
DOI:	10.1002/adhm.201400167