Drug Delivery: Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug (Adv. Healthcare Mater. 9/2014)

Drug Delivery: Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug (Adv. Healthcare Mater. 9/2014)

Automated parallel synthesis is applied by A. Postma, A. Zelikin, and team on page 1404 to obtain libraries of macromolecular prodrugs of ribavirin. Polymers differ in their average molar mass and drug content, the two parameters independently vary in broad respective ranges. Screening the libraries...

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Veröffentlicht in:Advanced healthcare materials 2014-09, Vol.3 (9), p.1520-1520
Hauptverfasser: Smith, Anton A. A., Wohl, Benjamin M., Kryger, Mille B. L., Hedemann, Natasha, Guerrero-Sanchez, Carlos, Postma, Almar, Zelikin, Alexander N.
Format: Artikel
Sprache:eng
Schlagworte:
drug delivery
high throughput screening
inflammation
polymers
prodrugs
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Zusammenfassung:Automated parallel synthesis is applied by A. Postma, A. Zelikin, and team on page 1404 to obtain libraries of macromolecular prodrugs of ribavirin. Polymers differ in their average molar mass and drug content, the two parameters independently vary in broad respective ranges. Screening the libraries for intracellular activity identifies at least 10 formulations with efficacy matching that of the drug and at the same time significantly reducing toxicity.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201470047