Organic Bioelectronics: Biomimetic Interfaces Reveal Activation Dynamics of C-Reactive Protein in Local Microenvironments (Adv. Healthcare Mater. 11/2014)

Organic Bioelectronics: Biomimetic Interfaces Reveal Activation Dynamics of C-Reactive Protein in Local Microenvironments (Adv. Healthcare Mater. 11/2014)

Alternation in local ionic microenvironments transforms the binding kinetics of pentameric C‐reactive protein to its receptor phosphorylcholine on a cell‐membrane‐mimetic surface. On page 1733 T. Goda and team show the biomimetic interface composed of a custom polymer and an organic bioelectronics t...

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Veröffentlicht in:Advanced healthcare materials 2014-11, Vol.3 (11), p.1693-1693
Hauptverfasser: Goda, Tatsuro, Kjall, Peter, Ishihara, Kazuhiko, Richter-Dahlfors, Agneta, Miyahara, Yuji
Format: Artikel
Sprache:eng
Schlagworte:
acute-phase reaction
C-reactive protein
inflammation
organic bioelectronics
phosphorylcholine
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Zusammenfassung:Alternation in local ionic microenvironments transforms the binding kinetics of pentameric C‐reactive protein to its receptor phosphorylcholine on a cell‐membrane‐mimetic surface. On page 1733 T. Goda and team show the biomimetic interface composed of a custom polymer and an organic bioelectronics to be a powerful tool in revealing the coherent picture of acute phase responses during inflammation and infection at molecular resolution.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201470054