Gene Delivery: Nonendocytic Delivery of Lipoplex Nanoparticles into Living Cells Using Nanochannel Electroporation (Adv. Healthcare Mater. 5/2014)

Gene Delivery: Nonendocytic Delivery of Lipoplex Nanoparticles into Living Cells Using Nanochannel Electroporation (Adv. Healthcare Mater. 5/2014)

Pouyan E. Boukany, L. James Lee, and colleagues have now found a safe, and efficient way to deliver nanoparticles containing a wide range of therapeutic agents into living cells without going through the endocytosis route, by applying electrical pulses through a nanochannel. The nanofluidic device i...

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Veröffentlicht in:Advanced healthcare materials 2014-05, Vol.3 (5), p.622-622
Hauptverfasser: Boukany, Pouyan E., Wu, Yun, Zhao, Xi, Kwak, Kwang J., Glazer, Piotr J., Leong, Kam, Lee, L. James
Format: Artikel
Sprache:eng
Schlagworte:
biomedical devices
Biomedical materials
Cells (biology)
Chemical compounds
Electroporation
Endocytosis
Fluidics
gene delivery
Gene expression
Gene transfer
lipoplexes
Nanochannels
nanofluidics
Nanofluids
Nanoparticles
Nucleic acids
Pharmacology
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Zusammenfassung:Pouyan E. Boukany, L. James Lee, and colleagues have now found a safe, and efficient way to deliver nanoparticles containing a wide range of therapeutic agents into living cells without going through the endocytosis route, by applying electrical pulses through a nanochannel. The nanofluidic device introduced on page 682 represents a novel platform for in vitro nucleic acid delivery in regulating gene expression and holds great potential in advancing fundamental biological science and modifying cells for biomedical applications.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201470023