MicroRNA-663 activates the canonical Wnt signaling through the adenomatous polyposis coli suppression

Highlights • MiR-663 is specifically up-regulated in RA patients compared with controls. • Increased miR-663 results in a marked reduction of APC expression. • MiR-663 indirectly affects the Wnt signaling by targeting APC. • MiR-663 displays an important role in the pathogenesis of RA.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2015-07, Vol.166 (1), p.45-54
Hauptverfasser:	Miao, Cheng-gui, Shi, Wei-jing, Xiong, You-yi, Yu, Hao, Zhang, Xiao-lin, Qin, Mei-song, Du, Chuan-lai, Song, Tong-wen, Zhang, Bing, Li, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Adenomatous polyposis coli Adenomatous Polyposis Coli Protein - biosynthesis Adenomatous Polyposis Coli Protein - genetics Adult Allergy and Immunology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - pathology beta Catenin - metabolism Binding Sites - genetics Canonical Wnt signaling pathway Cell Line Cell Proliferation Female Fibroblast-like synoviocytes Fibronectins - biosynthesis Humans Interleukin-6 - biosynthesis Interleukin-8 - biosynthesis Male Matrix Metalloproteinase 3 - biosynthesis microRNA-663 MicroRNAs - biosynthesis MicroRNAs - genetics Middle Aged Rheumatoid arthritis Synovial Membrane - cytology Synovial Membrane - metabolism Wnt Signaling Pathway - genetics
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Beschreibung
Zusammenfassung:	Highlights • MiR-663 is specifically up-regulated in RA patients compared with controls. • Increased miR-663 results in a marked reduction of APC expression. • MiR-663 indirectly affects the Wnt signaling by targeting APC. • MiR-663 displays an important role in the pathogenesis of RA.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2015.05.011