Cell Migration: Tunable Substrates Unveil Chemical Complementation of a Genetic Cell Migration Defect (Adv. Healthcare Mater. 8/2013)

Cell Migration: Tunable Substrates Unveil Chemical Complementation of a Genetic Cell Migration Defect (Adv. Healthcare Mater. 8/2013)

Sporozoite motility is essential for malaria transmission and constitutes the first target for intervention within the human body. On page 1162 J. P. Spatz, F. Frischknecht, and co‐workers use a set of tunable substrates with changed ligand spacing and elasticity to show that a small chemical compou...

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Veröffentlicht in:Advanced healthcare materials 2013-08, Vol.2 (8), p.1161-1161
Hauptverfasser: Hellmann, Janina Kristin, Perschmann, Nadine, Spatz, Joachim P., Frischknecht, Friedrich
Format: Artikel
Sprache:eng
Schlagworte:
actin
Apicomplexa
gliding motility
hydrogels
jasplakinolide
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Zusammenfassung:Sporozoite motility is essential for malaria transmission and constitutes the first target for intervention within the human body. On page 1162 J. P. Spatz, F. Frischknecht, and co‐workers use a set of tunable substrates with changed ligand spacing and elasticity to show that a small chemical compound that stabilizes the actin cytoskeleton can compensate the motility defects of parasites that lack a surface protein important for substrate adhesion.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201370044