Directing-Group-Assisted Copper-Catalyzed Olefinic Trifluoromethylation of Electron-Deficient Alkenes

Directing-Group-Assisted Copper-Catalyzed Olefinic Trifluoromethylation of Electron-Deficient Alkenes

Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis‐trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient metho...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-11, Vol.52 (47), p.12414-12417
Hauptverfasser: Feng, Chao, Loh, Teck-Peng
Format: Artikel
Sprache:eng
Schlagworte:
Acrylamide
Alkenes
Alkenes - chemical synthesis
Alkenes - chemistry
Carbon - chemistry
Catalysis
copper
Copper - chemistry
cross-coupling
CH activation
Derivatives
Electrons
Fluorine - chemistry
Formations
Functional groups
Hydrogen - chemistry
Methylation
Stereoisomerism
Synthesis
trifluoromethylation
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Beschreibung
Zusammenfassung:Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis‐trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β‐CF3‐functionalized acrylamide derivatives.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201307245