A Mild Benzannulation through Directed Cycloaddition Reactions

A Mild Benzannulation through Directed Cycloaddition Reactions

Simple as ABC: Alkynyl borane cycloadditions can be substrate‐directed to assemble aromatic difluoroboranes within an extremely mild and efficient reaction manifold compared to that of traditional methods (see scheme). The aromatic boranes are readily transformed into a range of useful products.

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Veröffentlicht in:Angewandte Chemie International Edition 2012-06, Vol.51 (26), p.6402-6405
Hauptverfasser: Kirkham, James D., Butlin, Roger J., Harrity, Joseph P. A.
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Benzene - chemistry
Boranes
boron
Boronic Acids - chemistry
cross-coupling
Cyclization
Cycloaddition
heterocycles
Manifolds
Molecular Structure
synthetic methods
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Zusammenfassung:Simple as ABC: Alkynyl borane cycloadditions can be substrate‐directed to assemble aromatic difluoroboranes within an extremely mild and efficient reaction manifold compared to that of traditional methods (see scheme). The aromatic boranes are readily transformed into a range of useful products.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201200917