Quantitative Emergence of Hetero[4]rotaxanes by Template-Directed Click Chemistry

In one fell swoop, polyrotaxanes comprising up to 64 rings can be synthesized as a result of cucurbit[6]uril‐templated 1,3‐dipolar azide‐alkyne cycloadditions accelerated in the presence of cyclodextrins as a consequence of self‐sorting and positive cooperativity, brought about by hydrogen bonding. Mixing six components (see picture) in one pot affords a hetero[4]rotaxane in one minute in quantitative yield.