Signal Transduction Using an Artificial Receptor System that Undergoes Dimerization Upon Addition of a Bivalent Leucine-Zipper Ligand

Examine your zipper: An artificial receptor system composed of an extracellular leucine‐zipper domain (red helices) fused to the transmembrane and cytoplasmic domains of the epidermal growth factor receptor (EGFR) is shown (see scheme). Dimerization and activation of the receptor is induced by a biv...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-07, Vol.51 (30), p.7464-7467
Hauptverfasser:	Nakase, Ikuhiko, Okumura, Shinya, Tanaka, Gen, Osaki, Katsuhiro, Imanishi, Miki, Futaki, Shiroh
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Cascades Cell Movement CHO Cells Cricetinae Dimerization epidermal growth factor Gene Expression Growth factors Helices Leucine Zippers leucine-zipper peptides Ligands Peptides - chemistry Peptides - metabolism Phosphorylation Protein Interaction Mapping Protein Multimerization Protein Structure, Secondary Protein Structure, Tertiary protein-protein interactions receptor dimerization Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Receptors Signal Transduction Zippers
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Beschreibung
Zusammenfassung:	Examine your zipper: An artificial receptor system composed of an extracellular leucine‐zipper domain (red helices) fused to the transmembrane and cytoplasmic domains of the epidermal growth factor receptor (EGFR) is shown (see scheme). Dimerization and activation of the receptor is induced by a bivalent leucine‐zipper ligand (blue helices), leading to phosphorylation of the cytoplasmic domain of the receptor, and eliciting a signaling cascade.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201201805