A General Pd-Catalyzed Decarboxylative Cross-Coupling Reaction between Aryl Carboxylic Acids: Synthesis of Biaryl Compounds

A General Pd-Catalyzed Decarboxylative Cross-Coupling Reaction between Aryl Carboxylic Acids: Synthesis of Biaryl Compounds

Acid to acid: A general method has been developed for the synthesis of biaryl compounds through a decarboxylative cross‐coupling reaction between two different (hetero)aryl carboxylic acids (see scheme). The use of a PdII/PCy3 catalyst enables the cross‐coupling reaction of electronically different...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-06, Vol.51 (24), p.5945-5949
Hauptverfasser: Hu, Peng, Shang, Yaping, Su, Weiping
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
biaryls
Carboxylic acids
Catalysts
Compatibility
cross-coupling
decarboxylation
heterocycles
Palladium
Synthesis
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Zusammenfassung:Acid to acid: A general method has been developed for the synthesis of biaryl compounds through a decarboxylative cross‐coupling reaction between two different (hetero)aryl carboxylic acids (see scheme). The use of a PdII/PCy3 catalyst enables the cross‐coupling reaction of electronically different or electronically similar aryl carboxylic acids. This method is compatible with substrates having nitro, cyano, fluoro, chloro, bromo, trifluoromethyl, and methoxy substituents.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201200153