Dynamic Display of Bioactivity through Host-Guest Chemistry

A molecular host, β‐cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS‐containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12077-12080
Hauptverfasser:	Boekhoven, Job, Rubert Pérez, Charles M., Sur, Shantanu, Worthy, Amanda, Stupp, Samuel I.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adhesion Alginates Animals beta-Cyclodextrins - chemistry Biochemistry biological signaling cell adhesion Cell Adhesion - drug effects Covalence Culture Dynamic control dynamics Extracellular Matrix - chemistry Extracellular Matrix - metabolism Fibroblasts host-guest chemistry Mice Microscopy, Confocal Oligopeptides - chemistry Oligopeptides - pharmacology Peptides - chemistry Peptides - pharmacology Spreading supramolecular chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A molecular host, β‐cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS‐containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non‐spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non‐bioactive sequence RGES.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201306278