Copper-Catalyzed Di- and Trifluoromethylation of [alpha],[beta]-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations

Copper-Catalyzed Di- and Trifluoromethylation of [alpha],[beta]-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations

Dual action: the Lewis acid CuF(2) 2H(2)O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,[beta]-unsaturated carboxylic acids by dually activating both reactants, thus affording di- and trifluoromethyl alkenes in high yields with excellent E/Z selectivity.

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Veröffentlicht in:Angewandte Chemie International Edition 2012-04, Vol.51 (16), p.3944-3947
Hauptverfasser: He, Zhengbiao, Luo, Tao, Hu, Mingyou, Cao, Yanjing, Hu, Jinbo
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Carboxylic acids
Lewis acid
Selectivity
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Zusammenfassung:Dual action: the Lewis acid CuF(2) 2H(2)O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,[beta]-unsaturated carboxylic acids by dually activating both reactants, thus affording di- and trifluoromethyl alkenes in high yields with excellent E/Z selectivity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201200140