Chemical Probes for Drug-Resistance Assessment by Binding Competition (RABC): Oseltamivir Susceptibility Evaluation

Chemical Probes for Drug-Resistance Assessment by Binding Competition (RABC): Oseltamivir Susceptibility Evaluation

The wizard of OS (resistance): The binding difference of neuraminidase inhibitors (zanamivir versus oseltamivir (OS)) was used to establish an assay to identify the influenza subtypes that are resistant to OS but still sensitive to zanamivir (see scheme). This assay used a zanamivir‐biotin conjugate...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-01, Vol.52 (1), p.366-370
Hauptverfasser: Cheng, Ting-Jen R., Wang, Shi-Yun, Wen, Wen-Hsien, Su, Ching-Yao, Lin, Mengi, Huang, Wen-I, Liu, Ming-Tsan, Wu, Ho-Sheng, Wang, Nung-Sen, Cheng, Chung-Kai, Chen, Chun-Lin, Ren, Chien-Tai, Wu, Chung-Yi, Fang, Jim-Min, Cheng, Yih-Shyun E., Wong, Chi-Huey
Format: Artikel
Sprache:eng
Schlagworte:
antiviral agents
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Assaying
Assessments
Binding
Binding, Competitive
Conjugates
drug resistance
Drug Resistance, Viral
Humans
Influenza
Influenza A Virus, H1N2 Subtype - drug effects
Inhibitors
microarrays
Operating systems
Oseltamivir - chemistry
Oseltamivir - pharmacology
sensors
Viruses
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Beschreibung
Zusammenfassung:The wizard of OS (resistance): The binding difference of neuraminidase inhibitors (zanamivir versus oseltamivir (OS)) was used to establish an assay to identify the influenza subtypes that are resistant to OS but still sensitive to zanamivir (see scheme). This assay used a zanamivir‐biotin conjugate to determine the OS susceptibility of a wide range of influenza viruses and over 200 clinical isolates.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201204062