Discovery of Chemoselective and Biocompatible Reactions Using a High-Throughput Immunoassay Screening
An immunoassay‐based method was used to screen numerous combinations of dipoles and dipolarophiles for their ability to undergo chemoselective and biocompatible [3+2] cycloaddition reactions. The approach fulfills most of the requirements of the click concept and led to the discovery of a copper‐cat...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12056-12060 |
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| container_issue | 46 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 52 |
| creator | Kolodych, Sergii Rasolofonjatovo, Evelia Chaumontet, Manon Nevers, Marie-Claire Créminon, Christophe Taran, Frédéric |
| description | An immunoassay‐based method was used to screen numerous combinations of dipoles and dipolarophiles for their ability to undergo chemoselective and biocompatible [3+2] cycloaddition reactions. The approach fulfills most of the requirements of the click concept and led to the discovery of a copper‐catalyzed reaction that generates pyrazoles from sydnone and alkyne reagents. |
| doi_str_mv | 10.1002/anie.201305645 |
| format | Article |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Alkynes Alkynes - chemistry Animals Azides - chemistry Biocompatibility Biocompatible Materials - analysis Catalysis Cattle click chemistry copper Copper - chemistry Cycloaddition Cycloaddition Reaction Dipoles high-throughput screening High-Throughput Screening Assays Immunoassay Phosphatidylcholines - chemistry Pyrazole reaction discovery Screening Screens Serum Albumin, Bovine - chemistry Sydnones - chemistry |
| title | Discovery of Chemoselective and Biocompatible Reactions Using a High-Throughput Immunoassay Screening |
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