Discovery of Chemoselective and Biocompatible Reactions Using a High-Throughput Immunoassay Screening

An immunoassay‐based method was used to screen numerous combinations of dipoles and dipolarophiles for their ability to undergo chemoselective and biocompatible [3+2] cycloaddition reactions. The approach fulfills most of the requirements of the click concept and led to the discovery of a copper‐cat...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12056-12060
Hauptverfasser:	Kolodych, Sergii, Rasolofonjatovo, Evelia, Chaumontet, Manon, Nevers, Marie-Claire, Créminon, Christophe, Taran, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Alkynes - chemistry Animals Azides - chemistry Biocompatibility Biocompatible Materials - analysis Catalysis Cattle click chemistry copper Copper - chemistry Cycloaddition Cycloaddition Reaction Dipoles high-throughput screening High-Throughput Screening Assays Immunoassay Phosphatidylcholines - chemistry Pyrazole reaction discovery Screening Screens Serum Albumin, Bovine - chemistry Sydnones - chemistry
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Beschreibung
Zusammenfassung:	An immunoassay‐based method was used to screen numerous combinations of dipoles and dipolarophiles for their ability to undergo chemoselective and biocompatible [3+2] cycloaddition reactions. The approach fulfills most of the requirements of the click concept and led to the discovery of a copper‐catalyzed reaction that generates pyrazoles from sydnone and alkyne reagents.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201305645