Ag super(I) Ion Mediated Formation of a C-A Mispair by DNA Polymerases

Ag super(I) Ion Mediated Formation of a C-A Mispair by DNA Polymerases

Silver turns up the A-C: In the presence of Ag super(I) ions, a DNA polymerase incorporated deoxyadenosine (from dATP) at the site opposite cytosine in the template strand to afford the full-length product (see scheme), meaning that DNA polymerases prefer a C-Ag super(I)-A base pair to the more ther...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-06, Vol.51 (26), p.6464-6466
Hauptverfasser: Funai, Tatsuya, Miyazaki, Yuki, Aotani, Megumi, Yamaguchi, Eriko, Nakagawa, Osamu, Wada, Shun-ichi, Torigoe, Hidetaka, Ono, Akira, Urata, Hidehito
Format: Artikel
Sprache:eng
Schlagworte:
DNA polymerase
Formations
Silver
Strands
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Zusammenfassung:Silver turns up the A-C: In the presence of Ag super(I) ions, a DNA polymerase incorporated deoxyadenosine (from dATP) at the site opposite cytosine in the template strand to afford the full-length product (see scheme), meaning that DNA polymerases prefer a C-Ag super(I)-A base pair to the more thermodynamically stable C-Ag super(I)-C base pair.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201109191