End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot‐scale plant used a novel route that incorporated many advantages of continuous‐flow processes to produce active pharmaceutical ingredients and the drug prod...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-11, Vol.52 (47), p.12359-12363
Hauptverfasser:	Mascia, Salvatore, Heider, Patrick L., Zhang, Haitao, Lakerveld, Richard, Benyahia, Brahim, Barton, Paul I., Braatz, Richard D., Cooney, Charles L., Evans, James M. B., Jamison, Timothy F., Jensen, Klavs F., Myerson, Allan S., Trout, Bernhardt L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - chemistry Amides - chemical synthesis Amides - chemistry Amides - isolation & purification Catalysis continuous processing Crystallization Dosage Drug Compounding Drugs flow chemistry Formations Fumarates - chemical synthesis Fumarates - chemistry Fumarates - isolation & purification Ingredients lactones Pharmaceutical Preparations - chemical synthesis Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - isolation & purification Pharmaceuticals protecting groups Purification Synthesis synthetic methods Technology, Pharmaceutical Tubes
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Beschreibung
Zusammenfassung:	A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot‐scale plant used a novel route that incorporated many advantages of continuous‐flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201305429