A Unique Family of Rigid Analogues of the GFP Chromophore with Tunable Two-Photon Action Cross-Sections for Biological Imaging

A Unique Family of Rigid Analogues of the GFP Chromophore with Tunable Two-Photon Action Cross-Sections for Biological Imaging

Conformationally restricted analogues of the GFP chromophore have been synthesized. The spectroscopic properties of GCTPOC, a unique family with tunable two‐photon action cross‐sections, were investigated. GCTPOC could be used as a robust two‐photon platform for development of a two‐photon fluoresce...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2013-09, Vol.52 (38), p.10018-10022
Hauptverfasser: Yuan, Lin, Lin, Weiying, Chen, Hua, Zhu, Sasa, He, Longwei
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical materials
Chromophores
Cross sections
fluorescence imaging
fluorescent dyes
Fluorescent Dyes - chemistry
fluorescent probes
GFP chromophore analogues
Green Fluorescent Proteins - chemistry
In vivo testing
In vivo tests
Molecular Conformation
Photons
Platforms
Spectrum Analysis
Surgical implants
Thiols
two-photon dyes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Conformationally restricted analogues of the GFP chromophore have been synthesized. The spectroscopic properties of GCTPOC, a unique family with tunable two‐photon action cross‐sections, were investigated. GCTPOC could be used as a robust two‐photon platform for development of a two‐photon fluorescent thiol sensor, which could stain endogenous thiols both in vitro and in vivo.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201303179