Long-Range Distances in Amyloid Fibrils of [alpha]-Synuclein from PELDOR Spectroscopy

Long-Range Distances in Amyloid Fibrils of [alpha]-Synuclein from PELDOR Spectroscopy

Distance measurements: Pulsed EPR distance measurements combined with strategic spin labeling provide structural constraints at the molecular level for the fold of α-synuclein in amyloid fibrils (see picture; r=distance). The detection of interstrand distances in fibrils will potentially make it pos...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-09, Vol.52 (39), p.10290-10294
Hauptverfasser: Pornsuwan, S, Giller, K, Riedel, D, Becker, S, Griesinger, C, Bennati, M
Format: Artikel
Sprache:eng
Schlagworte:
Marking
Pictures
Proteins
Spectroscopy
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Zusammenfassung:Distance measurements: Pulsed EPR distance measurements combined with strategic spin labeling provide structural constraints at the molecular level for the fold of α-synuclein in amyloid fibrils (see picture; r=distance). The detection of interstrand distances in fibrils will potentially make it possible to extend these measurements to oligomeric states of these protein families.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201304747