DNA hydrogel delivery vehicle for light-triggered and synergistic cancer therapy

A DNA hydrogel is reported as a delivery vehicle for gold nanorods and doxorubicin. The two photothermal and chemo cancer agents were co-loaded using electrostatic and DNA binding interactions, respectively. Light-triggered and highly synergistic combination cancer therapy was demonstrated in cellul...

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Veröffentlicht in:	Nanoscale 2015-06, Vol.7 (21), p.9433-9437
Hauptverfasser:	Song, Jaejung, Im, Kyuhyun, Hwang, Sekyu, Hur, Jaehyun, Nam, Jutaek, Ahn, G-One, Hwang, Sungwoo, Kim, Sungjee, Park, Nokyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Binding Cancer Cell Line, Tumor Deoxyribonucleic acid DNA - chemistry Doxorubicin - administration & dosage Drug Carriers - chemistry Gold - chemistry Humans Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogels Light Mice Nanorods Nanostructure Nanotubes - chemistry Nanotubes - ultrastructure Neoplasms - drug therapy Static Electricity Therapy Vehicles
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Beschreibung
Zusammenfassung:	A DNA hydrogel is reported as a delivery vehicle for gold nanorods and doxorubicin. The two photothermal and chemo cancer agents were co-loaded using electrostatic and DNA binding interactions, respectively. Light-triggered and highly synergistic combination cancer therapy was demonstrated in cellular and animal models.
ISSN:	2040-3364 2040-3372
DOI:	10.1039/c5nr00858a