Palladium/Copper-Catalyzed Oxidative CH Alkenylation/N-Dealkylative Carbonylation of Tertiary Anilines

CH/CN activation: The first palladium/copper‐catalyzed aerobic oxidative CH alkenylation/N‐dealkylative carbonylation of tertiary anilines has been developed. Various functional groups were tolerated and acrylic ester could also be suitable substrates. This transformation provided efficient and s...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-09, Vol.52 (40), p.10582-10585
Hauptverfasser:	Shi, Renyi, Lu, Lijun, Zhang, Hua, Chen, Borui, Sha, Yuchen, Liu, Chao, Lei, Aiwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic esters Activation Alkenes - chemical synthesis Alkenes - chemistry Alkylating Agents - chemistry aminocarbonylation Aniline Aniline Compounds - chemical synthesis Aniline Compounds - chemistry Carbonyls Catalysis Copper - chemistry CH activation CN bond activation Derivatives Indoles - chemical synthesis Indoles - chemistry indolin-2-ones Molecular Structure Organometallic Compounds - chemistry Oxidation-Reduction Palladium Palladium - chemistry Stereoisomerism Synthesis Transformations
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Zusammenfassung:	CH/CN activation: The first palladium/copper‐catalyzed aerobic oxidative CH alkenylation/N‐dealkylative carbonylation of tertiary anilines has been developed. Various functional groups were tolerated and acrylic ester could also be suitable substrates. This transformation provided efficient and straightforward synthesis of biologically active 3‐methyleneindolin‐2‐one derivatives from cheap and simple substrates.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201303911