Cavitand-Grafted Silicon Microcantilevers as a Universal Probe for Illicit and Designer Drugs in Water
The direct, clean, and unbiased transduction of molecular recognition into a readable and reproducible response is the biggest challenge associated to the use of synthetic receptors in sensing. All possible solutions demand the mastering of molecular recognition at the solid–liquid interface as prer...
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Veröffentlicht in: | Angewandte Chemie International Edition 2014-08, Vol.53 (35), p.9183-9188 |
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creator | Biavardi, Elisa Federici, Stefania Tudisco, Cristina Menozzi, Daniela Massera, Chiara Sottini, Andrea Condorelli, Guglielmo G. Bergese, Paolo Dalcanale, Enrico |
description | The direct, clean, and unbiased transduction of molecular recognition into a readable and reproducible response is the biggest challenge associated to the use of synthetic receptors in sensing. All possible solutions demand the mastering of molecular recognition at the solid–liquid interface as prerequisite. The socially relevant issue of screening amine‐based illicit and designer drugs is addressed by nanomechanical recognition at the silicon–water interface. The methylamino moieties of different drugs are all first recognized by a single cavitand receptor through a synergistic set of weak interactions. The peculiar recognition ability of the cavitand is then transferred with high fidelity and robustness on silicon microcantilevers and harnessed to realize a nanomechanical device for label‐free detection of these drugs in water.
Get them all! The widespread diffusion of methamphetamines and related designer drugs is a great challenge for our society, with significant impact on human health and social security. A cavitand‐grafted microcantilever device has been developed that is able to detect the whole class of methamphetamine drugs in water. This method acts independently of the type of residue attached to the target methylammonium unit. |
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Get them all! The widespread diffusion of methamphetamines and related designer drugs is a great challenge for our society, with significant impact on human health and social security. A cavitand‐grafted microcantilever device has been developed that is able to detect the whole class of methamphetamine drugs in water. This method acts independently of the type of residue attached to the target methylammonium unit.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201404774</identifier><identifier>PMID: 24909594</identifier><identifier>CODEN: ACIEAY</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>cantilevers ; cavitands ; designer drugs ; Designer Drugs - analysis ; Designer Drugs - chemistry ; Devices ; Drugs ; Illicit ; illicit drugs ; Methamphetamine ; Methamphetamine - analysis ; Methamphetamine - chemistry ; molecular recognition ; Molecular Structure ; Nanostructure ; Receptors ; Recognition ; Silicon ; Silicon - chemistry ; Substance Abuse Detection - methods ; Water - chemistry</subject><ispartof>Angewandte Chemie International Edition, 2014-08, Vol.53 (35), p.9183-9188</ispartof><rights>2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5804-7a347ee7f81dcfed71f61ae118f85c12210c58ec8d2c5fe6e46f996892f2a7ed3</citedby><cites>FETCH-LOGICAL-c5804-7a347ee7f81dcfed71f61ae118f85c12210c58ec8d2c5fe6e46f996892f2a7ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201404774$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201404774$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24909594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biavardi, Elisa</creatorcontrib><creatorcontrib>Federici, Stefania</creatorcontrib><creatorcontrib>Tudisco, Cristina</creatorcontrib><creatorcontrib>Menozzi, Daniela</creatorcontrib><creatorcontrib>Massera, Chiara</creatorcontrib><creatorcontrib>Sottini, Andrea</creatorcontrib><creatorcontrib>Condorelli, Guglielmo G.</creatorcontrib><creatorcontrib>Bergese, Paolo</creatorcontrib><creatorcontrib>Dalcanale, Enrico</creatorcontrib><title>Cavitand-Grafted Silicon Microcantilevers as a Universal Probe for Illicit and Designer Drugs in Water</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>The direct, clean, and unbiased transduction of molecular recognition into a readable and reproducible response is the biggest challenge associated to the use of synthetic receptors in sensing. All possible solutions demand the mastering of molecular recognition at the solid–liquid interface as prerequisite. The socially relevant issue of screening amine‐based illicit and designer drugs is addressed by nanomechanical recognition at the silicon–water interface. The methylamino moieties of different drugs are all first recognized by a single cavitand receptor through a synergistic set of weak interactions. The peculiar recognition ability of the cavitand is then transferred with high fidelity and robustness on silicon microcantilevers and harnessed to realize a nanomechanical device for label‐free detection of these drugs in water.
Get them all! The widespread diffusion of methamphetamines and related designer drugs is a great challenge for our society, with significant impact on human health and social security. A cavitand‐grafted microcantilever device has been developed that is able to detect the whole class of methamphetamine drugs in water. This method acts independently of the type of residue attached to the target methylammonium unit.</description><subject>cantilevers</subject><subject>cavitands</subject><subject>designer drugs</subject><subject>Designer Drugs - analysis</subject><subject>Designer Drugs - chemistry</subject><subject>Devices</subject><subject>Drugs</subject><subject>Illicit</subject><subject>illicit drugs</subject><subject>Methamphetamine</subject><subject>Methamphetamine - analysis</subject><subject>Methamphetamine - chemistry</subject><subject>molecular recognition</subject><subject>Molecular Structure</subject><subject>Nanostructure</subject><subject>Receptors</subject><subject>Recognition</subject><subject>Silicon</subject><subject>Silicon - chemistry</subject><subject>Substance Abuse Detection - methods</subject><subject>Water - chemistry</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rVDEUxYMoto5uXUrAjZs35vtjWaZ1HGhHsZZZhjTvpqS-ea8m71X735th6iBuChdyA79z4J6D0FtK5pQQ9tH3CeaMUEGE1uIZOqaS0YZrzZ_XXXDeaCPpEXpVym3ljSHqJTpiwhIrrThGceHv0-j7tllmH0do8WXqUhh6fJFCHoLvx9TBPeSCfR181afdx3f4ax6uAcch41VXFWnE1QWfQkk3PWR8mqebglOPN36E_Bq9iL4r8ObxnaGrT2ffF5-b8y_L1eLkvAnSENFoz4UG0NHQNkRoNY2KeqDURCMDZYySCkIwLQsyggKhorXKWBaZ19DyGfqw973Lw88Jyui2qQToOt_DMBVHNaE1N6nt06iUUjEha4gz9P4_9HaYcl8PcVQpIqykjFRqvqdqbqVkiO4up63PD44StyvL7cpyh7Kq4N2j7XS9hfaA_22nAnYP_KodPDxh507Wq7N_zZu9NpURfh-0Pv9wSnMt3Wa9dBt-qdnF-pvT_A_EoK8L</recordid><startdate>20140825</startdate><enddate>20140825</enddate><creator>Biavardi, Elisa</creator><creator>Federici, Stefania</creator><creator>Tudisco, Cristina</creator><creator>Menozzi, Daniela</creator><creator>Massera, Chiara</creator><creator>Sottini, Andrea</creator><creator>Condorelli, Guglielmo G.</creator><creator>Bergese, Paolo</creator><creator>Dalcanale, Enrico</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20140825</creationdate><title>Cavitand-Grafted Silicon Microcantilevers as a Universal Probe for Illicit and Designer Drugs in Water</title><author>Biavardi, Elisa ; Federici, Stefania ; Tudisco, Cristina ; Menozzi, Daniela ; Massera, Chiara ; Sottini, Andrea ; Condorelli, Guglielmo G. ; Bergese, Paolo ; Dalcanale, Enrico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5804-7a347ee7f81dcfed71f61ae118f85c12210c58ec8d2c5fe6e46f996892f2a7ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>cantilevers</topic><topic>cavitands</topic><topic>designer drugs</topic><topic>Designer Drugs - analysis</topic><topic>Designer Drugs - chemistry</topic><topic>Devices</topic><topic>Drugs</topic><topic>Illicit</topic><topic>illicit drugs</topic><topic>Methamphetamine</topic><topic>Methamphetamine - analysis</topic><topic>Methamphetamine - chemistry</topic><topic>molecular recognition</topic><topic>Molecular Structure</topic><topic>Nanostructure</topic><topic>Receptors</topic><topic>Recognition</topic><topic>Silicon</topic><topic>Silicon - chemistry</topic><topic>Substance Abuse Detection - methods</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biavardi, Elisa</creatorcontrib><creatorcontrib>Federici, Stefania</creatorcontrib><creatorcontrib>Tudisco, Cristina</creatorcontrib><creatorcontrib>Menozzi, Daniela</creatorcontrib><creatorcontrib>Massera, Chiara</creatorcontrib><creatorcontrib>Sottini, Andrea</creatorcontrib><creatorcontrib>Condorelli, Guglielmo G.</creatorcontrib><creatorcontrib>Bergese, Paolo</creatorcontrib><creatorcontrib>Dalcanale, Enrico</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biavardi, Elisa</au><au>Federici, Stefania</au><au>Tudisco, Cristina</au><au>Menozzi, Daniela</au><au>Massera, Chiara</au><au>Sottini, Andrea</au><au>Condorelli, Guglielmo G.</au><au>Bergese, Paolo</au><au>Dalcanale, Enrico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cavitand-Grafted Silicon Microcantilevers as a Universal Probe for Illicit and Designer Drugs in Water</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. Chem. Int. Ed</addtitle><date>2014-08-25</date><risdate>2014</risdate><volume>53</volume><issue>35</issue><spage>9183</spage><epage>9188</epage><pages>9183-9188</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>The direct, clean, and unbiased transduction of molecular recognition into a readable and reproducible response is the biggest challenge associated to the use of synthetic receptors in sensing. All possible solutions demand the mastering of molecular recognition at the solid–liquid interface as prerequisite. The socially relevant issue of screening amine‐based illicit and designer drugs is addressed by nanomechanical recognition at the silicon–water interface. The methylamino moieties of different drugs are all first recognized by a single cavitand receptor through a synergistic set of weak interactions. The peculiar recognition ability of the cavitand is then transferred with high fidelity and robustness on silicon microcantilevers and harnessed to realize a nanomechanical device for label‐free detection of these drugs in water.
Get them all! The widespread diffusion of methamphetamines and related designer drugs is a great challenge for our society, with significant impact on human health and social security. A cavitand‐grafted microcantilever device has been developed that is able to detect the whole class of methamphetamine drugs in water. This method acts independently of the type of residue attached to the target methylammonium unit.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>24909594</pmid><doi>10.1002/anie.201404774</doi><tpages>6</tpages><edition>International ed. in English</edition></addata></record> |
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subjects | cantilevers cavitands designer drugs Designer Drugs - analysis Designer Drugs - chemistry Devices Drugs Illicit illicit drugs Methamphetamine Methamphetamine - analysis Methamphetamine - chemistry molecular recognition Molecular Structure Nanostructure Receptors Recognition Silicon Silicon - chemistry Substance Abuse Detection - methods Water - chemistry |
title | Cavitand-Grafted Silicon Microcantilevers as a Universal Probe for Illicit and Designer Drugs in Water |
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