Lipase-modified pH-responsive microgel-based optical device for triglyceride sensing

Lipase-modified pH-responsive microgel-based optical device for triglyceride sensing

Lipase-modified pH-responsive poly(N-isopropylacrylamide)-based microgels were synthesized. An optical device was subsequently fabricated by sandwiching the enzyme loaded responsive microgels between two thin Au layers, and their response to triolein, a model triglyceride, was investigated. The devi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-06, Vol.51 (47), p.9726-9728
Hauptverfasser: Zhang, Qiang Matthew, Berg, Darren, Mugo, Samuel M, Serpe, Michael J
Format: Artikel
Sprache:eng
Schlagworte:
Acrylic Resins - chemistry
Biosensing Techniques - instrumentation
Biosensors
Detection
Devices
Enzymes
Gels
Gold
Gold - chemistry
Humans
Hydrogen-Ion Concentration
Lipase - chemistry
Lipase - metabolism
Microgels
Optical Devices
Polymers - chemistry
Surface Properties
Thin films
Triglycerides
Triglycerides - analysis
Triolein
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Beschreibung
Zusammenfassung:Lipase-modified pH-responsive poly(N-isopropylacrylamide)-based microgels were synthesized. An optical device was subsequently fabricated by sandwiching the enzyme loaded responsive microgels between two thin Au layers, and their response to triolein, a model triglyceride, was investigated. The device's response depended on the triglyceride concentration, demonstrating its potential application as a triglyceride biosensor.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc02853a