Identification of a Selective, Activity-Based Probe for Glyceraldehyde 3-Phosphate Dehydrogenases
Exceptionally specific: The natural‐product‐like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity‐based profiling probe (ABPP) Mrl‐Rh (Rh=rhodamine; see picture) for glyceraldehyde 3‐phosphate dehydrogenases. This probe can be used to invest...
Gespeichert in:
| Veröffentlicht in: | Angewandte Chemie International Edition 2012-05, Vol.51 (21), p.5230-5233 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5233 |
|---|---|
| container_issue | 21 |
| container_start_page | 5230 |
| container_title | Angewandte Chemie International Edition |
| container_volume | 51 |
| creator | Kaschani, Farnusch Clerc, Jérôme Krahn, Daniel Bier, David Hong, Tram Ngoc Ottmann, Christian Niessen, Sherry Colby, Tom van der Hoorn, Renier A. L. Kaiser, Markus |
| description | Exceptionally specific: The natural‐product‐like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity‐based profiling probe (ABPP) Mrl‐Rh (Rh=rhodamine; see picture) for glyceraldehyde 3‐phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions. |
| doi_str_mv | 10.1002/anie.201107276 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1701093526</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1014111985</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4446-2ad71363e2ade2657f461103a35273674841bb3ce66476a660ea4a2732223cc63</originalsourceid><addsrcrecordid>eNqNkctPGzEQxq2qVXn12mNlqRcObPBr7c0xhDREigLiUY6W451tTDfrYG-g-9_jKDRCvZTTjGZ-3yfNfAh9paRHCWGnpnHQY4RSopiSH9A-zRnNuFL8Y-oF55kqcrqHDmJ8SHxREPkZ7TEmij5RYh-ZSQlN6ypnTet8g32FDb6BGmzrnuAEDzbVtV12ZiKU-Cr4OeDKBzyuOwvB1CUsuhIwz64WPq4WpgV8vhkF_wuapIlH6FNl6ghfXushuvsxuh1eZNPL8WQ4mGZWCCEzZkpFueSQGmAyV5WQ6SpueM4Ul0oUgs7n3IKUQkkjJQEjTFoxxri1kh-i463vKvjHNcRWL120UNemAb-OmipCST-5vQMlVFBK-0We0O__oA9-HZp0iE7fTRGkxxeJ6m0pG3yMASq9Cm5pQpes9CYnvclJ73JKgm-vtuv5Esod_jeYBPS3wLOrofuPnR7MJqO35tlW62ILf3ZaE35rqbjK9f1srO9_zq6L4e1MT_kLbtarvA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1431001078</pqid></control><display><type>article</type><title>Identification of a Selective, Activity-Based Probe for Glyceraldehyde 3-Phosphate Dehydrogenases</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kaschani, Farnusch ; Clerc, Jérôme ; Krahn, Daniel ; Bier, David ; Hong, Tram Ngoc ; Ottmann, Christian ; Niessen, Sherry ; Colby, Tom ; van der Hoorn, Renier A. L. ; Kaiser, Markus</creator><creatorcontrib>Kaschani, Farnusch ; Clerc, Jérôme ; Krahn, Daniel ; Bier, David ; Hong, Tram Ngoc ; Ottmann, Christian ; Niessen, Sherry ; Colby, Tom ; van der Hoorn, Renier A. L. ; Kaiser, Markus</creatorcontrib><description>Exceptionally specific: The natural‐product‐like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity‐based profiling probe (ABPP) Mrl‐Rh (Rh=rhodamine; see picture) for glyceraldehyde 3‐phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201107276</identifier><identifier>PMID: 22489074</identifier><identifier>CODEN: ACIEAY</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>activity-based protein profiling ; chemical biology ; chemical proteomics ; Chromatography, Liquid ; Complexity ; Electrophoresis, Polyacrylamide Gel ; Enzymes ; Feasibility Studies ; GAPDH ; Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism ; Hydantoin ; inhibitors ; Molecular Probes ; Pictures ; Profiling ; Tandem Mass Spectrometry</subject><ispartof>Angewandte Chemie International Edition, 2012-05, Vol.51 (21), p.5230-5233</ispartof><rights>Copyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4446-2ad71363e2ade2657f461103a35273674841bb3ce66476a660ea4a2732223cc63</citedby><cites>FETCH-LOGICAL-c4446-2ad71363e2ade2657f461103a35273674841bb3ce66476a660ea4a2732223cc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201107276$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201107276$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22489074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaschani, Farnusch</creatorcontrib><creatorcontrib>Clerc, Jérôme</creatorcontrib><creatorcontrib>Krahn, Daniel</creatorcontrib><creatorcontrib>Bier, David</creatorcontrib><creatorcontrib>Hong, Tram Ngoc</creatorcontrib><creatorcontrib>Ottmann, Christian</creatorcontrib><creatorcontrib>Niessen, Sherry</creatorcontrib><creatorcontrib>Colby, Tom</creatorcontrib><creatorcontrib>van der Hoorn, Renier A. L.</creatorcontrib><creatorcontrib>Kaiser, Markus</creatorcontrib><title>Identification of a Selective, Activity-Based Probe for Glyceraldehyde 3-Phosphate Dehydrogenases</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>Exceptionally specific: The natural‐product‐like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity‐based profiling probe (ABPP) Mrl‐Rh (Rh=rhodamine; see picture) for glyceraldehyde 3‐phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions.</description><subject>activity-based protein profiling</subject><subject>chemical biology</subject><subject>chemical proteomics</subject><subject>Chromatography, Liquid</subject><subject>Complexity</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Enzymes</subject><subject>Feasibility Studies</subject><subject>GAPDH</subject><subject>Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism</subject><subject>Hydantoin</subject><subject>inhibitors</subject><subject>Molecular Probes</subject><subject>Pictures</subject><subject>Profiling</subject><subject>Tandem Mass Spectrometry</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctPGzEQxq2qVXn12mNlqRcObPBr7c0xhDREigLiUY6W451tTDfrYG-g-9_jKDRCvZTTjGZ-3yfNfAh9paRHCWGnpnHQY4RSopiSH9A-zRnNuFL8Y-oF55kqcrqHDmJ8SHxREPkZ7TEmij5RYh-ZSQlN6ypnTet8g32FDb6BGmzrnuAEDzbVtV12ZiKU-Cr4OeDKBzyuOwvB1CUsuhIwz64WPq4WpgV8vhkF_wuapIlH6FNl6ghfXushuvsxuh1eZNPL8WQ4mGZWCCEzZkpFueSQGmAyV5WQ6SpueM4Ul0oUgs7n3IKUQkkjJQEjTFoxxri1kh-i463vKvjHNcRWL120UNemAb-OmipCST-5vQMlVFBK-0We0O__oA9-HZp0iE7fTRGkxxeJ6m0pG3yMASq9Cm5pQpes9CYnvclJ73JKgm-vtuv5Esod_jeYBPS3wLOrofuPnR7MJqO35tlW62ILf3ZaE35rqbjK9f1srO9_zq6L4e1MT_kLbtarvA</recordid><startdate>20120521</startdate><enddate>20120521</enddate><creator>Kaschani, Farnusch</creator><creator>Clerc, Jérôme</creator><creator>Krahn, Daniel</creator><creator>Bier, David</creator><creator>Hong, Tram Ngoc</creator><creator>Ottmann, Christian</creator><creator>Niessen, Sherry</creator><creator>Colby, Tom</creator><creator>van der Hoorn, Renier A. L.</creator><creator>Kaiser, Markus</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20120521</creationdate><title>Identification of a Selective, Activity-Based Probe for Glyceraldehyde 3-Phosphate Dehydrogenases</title><author>Kaschani, Farnusch ; Clerc, Jérôme ; Krahn, Daniel ; Bier, David ; Hong, Tram Ngoc ; Ottmann, Christian ; Niessen, Sherry ; Colby, Tom ; van der Hoorn, Renier A. L. ; Kaiser, Markus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4446-2ad71363e2ade2657f461103a35273674841bb3ce66476a660ea4a2732223cc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>activity-based protein profiling</topic><topic>chemical biology</topic><topic>chemical proteomics</topic><topic>Chromatography, Liquid</topic><topic>Complexity</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Enzymes</topic><topic>Feasibility Studies</topic><topic>GAPDH</topic><topic>Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism</topic><topic>Hydantoin</topic><topic>inhibitors</topic><topic>Molecular Probes</topic><topic>Pictures</topic><topic>Profiling</topic><topic>Tandem Mass Spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaschani, Farnusch</creatorcontrib><creatorcontrib>Clerc, Jérôme</creatorcontrib><creatorcontrib>Krahn, Daniel</creatorcontrib><creatorcontrib>Bier, David</creatorcontrib><creatorcontrib>Hong, Tram Ngoc</creatorcontrib><creatorcontrib>Ottmann, Christian</creatorcontrib><creatorcontrib>Niessen, Sherry</creatorcontrib><creatorcontrib>Colby, Tom</creatorcontrib><creatorcontrib>van der Hoorn, Renier A. L.</creatorcontrib><creatorcontrib>Kaiser, Markus</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaschani, Farnusch</au><au>Clerc, Jérôme</au><au>Krahn, Daniel</au><au>Bier, David</au><au>Hong, Tram Ngoc</au><au>Ottmann, Christian</au><au>Niessen, Sherry</au><au>Colby, Tom</au><au>van der Hoorn, Renier A. L.</au><au>Kaiser, Markus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a Selective, Activity-Based Probe for Glyceraldehyde 3-Phosphate Dehydrogenases</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. Chem. Int. Ed</addtitle><date>2012-05-21</date><risdate>2012</risdate><volume>51</volume><issue>21</issue><spage>5230</spage><epage>5233</epage><pages>5230-5233</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>Exceptionally specific: The natural‐product‐like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity‐based profiling probe (ABPP) Mrl‐Rh (Rh=rhodamine; see picture) for glyceraldehyde 3‐phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>22489074</pmid><doi>10.1002/anie.201107276</doi><tpages>4</tpages><edition>International ed. in English</edition></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2012-05, Vol.51 (21), p.5230-5233 |
| issn | 1433-7851 1521-3773 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1701093526 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | activity-based protein profiling chemical biology chemical proteomics Chromatography, Liquid Complexity Electrophoresis, Polyacrylamide Gel Enzymes Feasibility Studies GAPDH Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Hydantoin inhibitors Molecular Probes Pictures Profiling Tandem Mass Spectrometry |
| title | Identification of a Selective, Activity-Based Probe for Glyceraldehyde 3-Phosphate Dehydrogenases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T12%3A15%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identification%20of%20a%20Selective,%20Activity-Based%20Probe%20for%20Glyceraldehyde%203-Phosphate%20Dehydrogenases&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.au=Kaschani,%20Farnusch&rft.date=2012-05-21&rft.volume=51&rft.issue=21&rft.spage=5230&rft.epage=5233&rft.pages=5230-5233&rft.issn=1433-7851&rft.eissn=1521-3773&rft.coden=ACIEAY&rft_id=info:doi/10.1002/anie.201107276&rft_dat=%3Cproquest_cross%3E1014111985%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1431001078&rft_id=info:pmid/22489074&rfr_iscdi=true |