Frame-Guided Assembly of Vesicles with Programmed Geometry and Dimensions

In molecular self‐assembly molecules form organized structures or patterns. The control of the self‐assembly process is an important and challenging topic. Inspired by the cytoskeletal‐membrane protein lipid bilayer system that determines the shape of eukaryotic cells, we developed a frame‐guided assembly process as a general strategy to prepare heterovesicles with programmed geometry and dimensions. This method offers greater control over self‐assembly which may benefit the understanding of the formation mechanism as well as the functions of the cell membrane. Diskontinuierliche hydrophobe Führungsgruppen (LHGs) wurden an ein Grundgerüst gebunden, um auf diese Weise den Rahmen der zu synthetisierenden Struktur zu definieren. Das Gerüst führt andere amphiphile Moleküle in die Lücken zwischen den LHGs, was letztlich in der Bildung von Heterovesikeln mit einstellbarer Form und Größe resultiert.