Cisplatin binding to human serum albumin: a structural study

Cisplatin binding to human serum albumin: a structural study

The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; addit...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-06, Vol.51 (46), p.9436-9439
Hauptverfasser: Ferraro, Giarita, Massai, Lara, Messori, Luigi, Merlino, Antonello
Format: Artikel
Sprache:eng
Schlagworte:
Adducts
Binding
Binding Sites
Cisplatin - chemistry
Crystal structure
Crystallography
Crystallography, X-Ray
Human
Humans
Molecular Conformation
Serum albumin
Serum Albumin - chemistry
X-rays
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Beschreibung
Zusammenfassung:The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc01751c