Stereodivergent Synthesis of Arylcyclopropylamines by Sequential CH Borylation and Suzuki-Miyaura Coupling

A step‐economical and stereodivergent synthesis of privileged 2‐arylcyclopropylamines (ACPAs) through a C(sp3)H borylation and Suzuki–Miyaura coupling sequence has been developed. The iridium‐catalyzed CH borylation of N‐cyclopropylpivalamide proceeds with cis selectivity. The subsequent B‐cyclopr...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-01, Vol.54 (3), p.846-851
Hauptverfasser:	Miyamura, Shin, Araki, Misaho, Suzuki, Takayoshi, Yamaguchi, Junichiro, Itami, Kenichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Atmospheres Bearing boron Boron - chemistry Carbon Carbon - chemistry Catalysis cross-coupling Crystallography, X-Ray Cyclopropanes - chemical synthesis Cyclopropanes - chemistry CH activation Derivatives Hydrogen - chemistry iridium Iridium - chemistry Isomers Joining Molecular Conformation Selectivity small ring systems Stereoisomerism Synthesis
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