A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells

Mitochondrial dynamics: An image‐based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects cells from mitochondrial‐fragmentation‐associated cell death. Mechanistic studies revealed that M1 shifts the mitochondrial dynamic balance tow...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-09, Vol.51 (37), p.9302-9305
Hauptverfasser:	Wang, Danling, Wang, Jianing, Bonamy, Ghislain M. C., Meeusen, Shelly, Brusch, Richard G., Turk, Carolina, Yang, Pengyu, Schultz, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP synthase Balancing Cell death Cell Line Cell Survival - drug effects drug design Dynamic tests Dynamics Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Fragmentation GTP Phosphohydrolases - deficiency GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Humans Hydrazones - chemistry Hydrazones - pharmacology Hydrocarbons, Chlorinated - chemistry Hydrocarbons, Chlorinated - pharmacology Mice Microscopy, Confocal Mitochondria Mitochondria - metabolism Mitochondrial Dynamics - drug effects mitochondrial fusion Mitochondrial Proton-Translocating ATPases - metabolism Oxidative Phosphorylation Coupling Factors - metabolism phenotypic screening Pictures Screens
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