A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells

Mitochondrial dynamics: An image‐based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects cells from mitochondrial‐fragmentation‐associated cell death. Mechanistic studies revealed that M1 shifts the mitochondrial dynamic balance tow...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-09, Vol.51 (37), p.9302-9305
Hauptverfasser:	Wang, Danling, Wang, Jianing, Bonamy, Ghislain M. C., Meeusen, Shelly, Brusch, Richard G., Turk, Carolina, Yang, Pengyu, Schultz, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP synthase Balancing Cell death Cell Line Cell Survival - drug effects drug design Dynamic tests Dynamics Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Fragmentation GTP Phosphohydrolases - deficiency GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Humans Hydrazones - chemistry Hydrazones - pharmacology Hydrocarbons, Chlorinated - chemistry Hydrocarbons, Chlorinated - pharmacology Mice Microscopy, Confocal Mitochondria Mitochondria - metabolism Mitochondrial Dynamics - drug effects mitochondrial fusion Mitochondrial Proton-Translocating ATPases - metabolism Oxidative Phosphorylation Coupling Factors - metabolism phenotypic screening Pictures Screens
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Beschreibung
Zusammenfassung:	Mitochondrial dynamics: An image‐based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects cells from mitochondrial‐fragmentation‐associated cell death. Mechanistic studies revealed that M1 shifts the mitochondrial dynamic balance towards fusion (see picture).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201204589