On resin synthesis and cross-linking of collagen peptides containing the advanced glycation end-product pyrraline viaMaillard condensation

On resin synthesis and cross-linking of collagen peptides containing the advanced glycation end-product pyrraline viaMaillard condensation

Glycation and its products cause a host of pathological conditions but their exact roles are yet to be determined. Pyrraline, a key product of glycation, and a novel pyrraline-derived cross-link have been incorporated into collagenous peptides viaMaillard condensations performed on resin-bound pepti...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-05, Vol.51 (46), p.9475-9478
Hauptverfasser: Kamalov, Meder, Harris, Paul WR, Wood, James M, Brimble, Margaret A
Format: Artikel
Sprache:eng
Schlagworte:
Collagens
Condensates
Condensation resins
Crosslinking
Peptides
Polymers
Resins
Synthesis
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Beschreibung
Zusammenfassung:Glycation and its products cause a host of pathological conditions but their exact roles are yet to be determined. Pyrraline, a key product of glycation, and a novel pyrraline-derived cross-link have been incorporated into collagenous peptides viaMaillard condensations performed on resin-bound peptide sequences.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc03052h