NHC-Catalyzed Hydroacylation of Styrenes

NHC-Catalyzed Hydroacylation of Styrenes

New hydroacylation catalysts: Highly electron‐rich N‐heterocyclic carbenes (NHCs) facilitate the intermolecular hydroacylation of unstrained olefins. This unprecedented organocatalytic coupling joins simple and abundant aldehydes and styrenes to yield valuable ketone products. EWG=electron‐withdrawi...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-02, Vol.52 (9), p.2585-2589
Hauptverfasser: Schedler, Michael, Wang, Duo-Sheng, Glorius, Frank
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Carbenes
hydroacylation
Joining
Ketones
N-heterocyclic carbenes
Olefins
organocatalysis
Styrenes
synthetic methods
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Beschreibung
Zusammenfassung:New hydroacylation catalysts: Highly electron‐rich N‐heterocyclic carbenes (NHCs) facilitate the intermolecular hydroacylation of unstrained olefins. This unprecedented organocatalytic coupling joins simple and abundant aldehydes and styrenes to yield valuable ketone products. EWG=electron‐withdrawing group, EDG=electron‐donating group.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201209291