Total Syntheses of (-)-ScabroninesG and A, and (-)-EpiscabronineA

Total Syntheses of (-)-ScabroninesG and A, and (-)-EpiscabronineA

Making scab(ronine)s: The total synthesis of (-)-scabronineG features a highly stereoselective oxidative dearomatization/intramolecular inverse-electron-demand Diels-Alder reaction cascade, and the first total synthesis of (-)-scabronineA comprises a highly stereoselective oxa-Michael/protonation/ac...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-07, Vol.52 (29), p.7569-7573
Hauptverfasser: Kobayakawa, Yu, Nakada, Masahisa
Format: Artikel
Sprache:eng
Schlagworte:
Cascades
Diels-Alder reactions
Protonation
Synthesis
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Beschreibung
Zusammenfassung:Making scab(ronine)s: The total synthesis of (-)-scabronineG features a highly stereoselective oxidative dearomatization/intramolecular inverse-electron-demand Diels-Alder reaction cascade, and the first total synthesis of (-)-scabronineA comprises a highly stereoselective oxa-Michael/protonation/acetalization cascade. The first total synthesis of (-)-episcabronineA includes another highly stereoselective cascade.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201303224