A nanobody-based electrochemiluminescent immunosensor for sensitive detection of human procalcitonin

The development of a nanobody-based electrochemiluminescent immunosensor for procalcitonin quantification is described. A highly specific and enhanced sensitivity of target detection was achieved by CdTe quantum dot encapsulated silica nanoparticle-assisted signal amplification.

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Bibliographische Detailangaben
Veröffentlicht in:	Analyst (London) 2014-01, Vol.139 (15), p.3718-3721
Hauptverfasser:	Li, Henan, Sun, Yanyan, Elseviers, Jelle, Muyldermans, Serge, Liu, Songqin, Wan, Yakun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amplification Biosensing Techniques - instrumentation Cadmium Compounds - chemistry Cadmium tellurides Calcitonin - analysis Calcitonin - blood Calcitonin Gene-Related Peptide Electrochemical Techniques - instrumentation Encapsulation Equipment Design Human Humans Immunoassay - instrumentation Immunosensors Limit of Detection Luminescent Measurements - instrumentation Molecular Sequence Data Nanoparticles - chemistry Nanostructure Protein Precursors - analysis Protein Precursors - blood Quantum dots Quantum Dots - chemistry Silicon dioxide Silicon Dioxide - chemistry Tellurium - chemistry
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Beschreibung
Zusammenfassung:	The development of a nanobody-based electrochemiluminescent immunosensor for procalcitonin quantification is described. A highly specific and enhanced sensitivity of target detection was achieved by CdTe quantum dot encapsulated silica nanoparticle-assisted signal amplification.
ISSN:	0003-2654 1364-5528
DOI:	10.1039/c4an00626g