Metal-Free Cross-Dehydrogenative Coupling of Heterocycles with Aldehydes

A range of heterocyclic compounds were synthesized by a novel, metal‐free cross‐dehydrogenative coupling between heterocycles and aldehydes under mild reaction conditions that are not sensitive to moisture. The products are formed smoothly and regioselectively at room temperature by a hypervalent io...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-02, Vol.52 (7), p.2082-2086
Hauptverfasser:	Matcha, Kiran, Antonchick, Andrey P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Aldehydes - chemistry alkaloids Alkaloids - chemistry Catalysis heterocycles Heterocyclic compounds Heterocyclic Compounds - chemistry Hydrogenation hypervalent iodine Iodine Iodine - chemistry Joining metal-free Metals - chemistry Moisture Natural products radicals Solvents - chemistry Synthesis Transformations
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Beschreibung
Zusammenfassung:	A range of heterocyclic compounds were synthesized by a novel, metal‐free cross‐dehydrogenative coupling between heterocycles and aldehydes under mild reaction conditions that are not sensitive to moisture. The products are formed smoothly and regioselectively at room temperature by a hypervalent iodine mediated transformation. This method has a broad substrate scope and was used in the highly efficient, one‐step synthesis of natural products.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201208851