Sandmeyer Trifluoromethylation of Arenediazonium Tetrafluoroborates

Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl–copper complex generated in situ from CuSCN and the inexpensive, easy‐to‐use trifluoromethylating reagent Me3Si‐CF3 (see scheme). This Sandmeyer‐type reaction al...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-07, Vol.52 (31), p.7972-7975
Hauptverfasser:	Danoun, Grégory, Bayarmagnai, Bilguun, Grünberg, Matthias F., Gooßen, Lukas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMINES Aromatic compounds Borates - chemistry CONVERTERS Coordination Complexes - chemistry Copper Copper - chemistry Copper converters Derivatives Diazonium Compounds - chemistry diazonium salts FABRICATION Fluorine - chemistry Methylation Sandmeyer reaction Synthesis trifluoromethylation
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Beschreibung
Zusammenfassung:	Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl–copper complex generated in situ from CuSCN and the inexpensive, easy‐to‐use trifluoromethylating reagent Me3Si‐CF3 (see scheme). This Sandmeyer‐type reaction allows the straightforward synthesis of trifluoromethylated arenes and heteroarenes from the corresponding amines.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201304276