Kinetic Resolution of Tertiary Alcohols: Highly Enantioselective Access to 3-Hydroxy-3-Substituted Oxindoles
Enantioselective: The first highly enantioselective kinetic resolution of 3‐hydroxy‐3‐substituted oxindoles has been developed through oxidative esterification catalyzed by a N‐heterocyclic carbene (see picture). This method uses a simple procedure and provides 3‐hydroxy‐oxindoles with various subst...
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Veröffentlicht in: | Angewandte Chemie International Edition 2013-02, Vol.52 (6), p.1731-1734 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Enantioselective: The first highly enantioselective kinetic resolution of 3‐hydroxy‐3‐substituted oxindoles has been developed through oxidative esterification catalyzed by a N‐heterocyclic carbene (see picture). This method uses a simple procedure and provides 3‐hydroxy‐oxindoles with various substituents at the 3‐position in excellent enantiopurity. S=selectivity. |
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ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.201209043 |