Kinetic Resolution of Tertiary Alcohols: Highly Enantioselective Access to 3-Hydroxy-3-Substituted Oxindoles

Enantioselective: The first highly enantioselective kinetic resolution of 3‐hydroxy‐3‐substituted oxindoles has been developed through oxidative esterification catalyzed by a N‐heterocyclic carbene (see picture). This method uses a simple procedure and provides 3‐hydroxy‐oxindoles with various subst...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-02, Vol.52 (6), p.1731-1734
Hauptverfasser: Lu, Shenci, Poh, Si Bei, Siau, Woon-Yew, Zhao, Yu
Format: Artikel
Sprache:eng
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Zusammenfassung:Enantioselective: The first highly enantioselective kinetic resolution of 3‐hydroxy‐3‐substituted oxindoles has been developed through oxidative esterification catalyzed by a N‐heterocyclic carbene (see picture). This method uses a simple procedure and provides 3‐hydroxy‐oxindoles with various substituents at the 3‐position in excellent enantiopurity. S=selectivity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201209043