Chiral N-Heterocyclic Carbene/Pyridine Ligands for the Iridium-Catalyzed Asymmetric Hydrogenation of Olefins

Chiral N-Heterocyclic Carbene/Pyridine Ligands for the Iridium-Catalyzed Asymmetric Hydrogenation of Olefins

Swapping N,P for C,N: Iridium complexes of bidentate pyridine‐based C,N ligands with an N‐heterocylic carbene (NHC) unit proved to be efficient and highly enantioselective hydrogenation catalysts. As a result of the lower acidity of iridium hydride intermediates produced from NHC‐based complexes, th...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-07, Vol.52 (29), p.7422-7425
Hauptverfasser: Schumacher, Andreas, Bernasconi, Maurizio, Pfaltz, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
alkenes
asymmetric catalysis
Asymmetry
Carbenes
Catalysis
Catalysts
Hydrogenation
Iridium
Ligands
N heterocyclic carbene
Olefins
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Zusammenfassung:Swapping N,P for C,N: Iridium complexes of bidentate pyridine‐based C,N ligands with an N‐heterocylic carbene (NHC) unit proved to be efficient and highly enantioselective hydrogenation catalysts. As a result of the lower acidity of iridium hydride intermediates produced from NHC‐based complexes, these catalysts are much better suited than analogous N,P‐ligand complexes for the hydrogenation of acid‐sensitive substrates.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201301251