Cooperative Catalysis through Noncovalent Interactions

Cooperative Catalysis through Noncovalent Interactions

One of four: A chiral phosphoric acid enables asymmetric hydrogenation of imines with an achiral iridium catalyst by virtue of noncovalent interactions. These interactions lead to the formation of a highly organized ternary complex, and the hydride is transferred highly enantioselectively.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2013-02, Vol.52 (6), p.1668-1672
Hauptverfasser: Tang, Weijun, Johnston, Steven, Iggo, Jonathan A., Berry, Neil G., Phelan, Marie, Lian, Luyun, Bacsa, John, Xiao, Jianliang
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetry
Brønsted acid
Catalysis
cooperative catalysis
Coordination Complexes - chemistry
Crystallography, X-Ray
Formations
Hydrides
Hydrogenation
Imines
Imines - chemistry
Iridium
Iridium - chemistry
Molecular Conformation
noncovalent interactions
Phosphoric acid
Phosphoric Acids - chemistry
Stereoisomerism
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Beschreibung
Zusammenfassung:One of four: A chiral phosphoric acid enables asymmetric hydrogenation of imines with an achiral iridium catalyst by virtue of noncovalent interactions. These interactions lead to the formation of a highly organized ternary complex, and the hydride is transferred highly enantioselectively.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201208774