Enantioselective Cyanoethoxycarbonylation of Isatins Promoted by a Lewis Base-Broensted Acid Cooperative Catalyst

Enantioselective Cyanoethoxycarbonylation of Isatins Promoted by a Lewis Base-Broensted Acid Cooperative Catalyst

Teaming up to make it happen: In the title reaction, the Lewis basic site of the catalyst activated ethyl cyanoformate, and the deep and flexible Broensted acidic cavity stabilized and selectively recognized the key reaction intermediate to promote asymmetric acylation (see scheme).

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2013-08, Vol.52 (32), p.8299-8303
Hauptverfasser: Ogura, Yoshihiro, Akakura, Matsujiro, Sakakura, Akira, Ishihara, Kazuaki
Format: Artikel
Sprache:eng
Schlagworte:
Activated
Acylation
Asymmetry
Catalysts
Holes
Recognition
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Beschreibung
Zusammenfassung:Teaming up to make it happen: In the title reaction, the Lewis basic site of the catalyst activated ethyl cyanoformate, and the deep and flexible Broensted acidic cavity stabilized and selectively recognized the key reaction intermediate to promote asymmetric acylation (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201303572