Reversible pH-controlled switching of an artificial antioxidant selenoenzyme based on pseudorotaxane formation and dissociation

Reversible pH-controlled switching of an artificial antioxidant selenoenzyme based on pseudorotaxane formation and dissociation

A pH-responsive artificial selenoenzyme was constructed by reversible binding between organoselenium compound a1 nd CB[6] to form a pseudorotaxane-based molecular switch in response to pH stimuli. The glutathione peroxidase (GPx) activity of the artificial selenoenzyme can be switched on/off in a mi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-06, Vol.51 (49), p.9987-9990
Hauptverfasser: Li, Jiaxi, Si, Chengye, Sun, Hongcheng, Zhu, Junyan, Pan, Tiezheng, Liu, Shengda, Dong, Zeyuan, Xu, Jiayun, Luo, Quan, Liu, Junqiu
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidants
Binding
Biomimetic Materials - chemistry
Bridged-Ring Compounds - chemistry
Glutathione Peroxidase - chemistry
Glutathione Peroxidase - metabolism
Hydrogen-Ion Concentration
Imidazoles - chemistry
Models, Molecular
Molecular Conformation
Organoselenium compounds
Organoselenium Compounds - chemistry
Peroxidase
Rotaxanes - chemistry
Stimuli
Switches
Switching
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Zusammenfassung:A pH-responsive artificial selenoenzyme was constructed by reversible binding between organoselenium compound a1 nd CB[6] to form a pseudorotaxane-based molecular switch in response to pH stimuli. The glutathione peroxidase (GPx) activity of the artificial selenoenzyme can be switched on/off in a mild and body suitable environment between pH = 7 and pH = 6.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc02038g