Dehydrogenative Coupling to Enable the Enantioselective Total Synthesis of (-)-Simaomicin [alpha]
The anticancer natural product simaomicinα has been synthesized. Asymmetric synthesis allowed the assignment of absolute stereochemistry. The enantiomer of the naturally occurring substance shows potent cytotoxicity towards Gram-positive bacteria and human cancer cells. Bn=benzyl, BOM=benzyloxymethy...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2013-10, Vol.52 (41), p.10796-10799 |
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| container_end_page | 10799 |
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| container_issue | 41 |
| container_start_page | 10796 |
| container_title | Angewandte Chemie International Edition |
| container_volume | 52 |
| creator | Wang, Yizhong Wang, Chao Butler, John R Ready, Joseph M |
| description | The anticancer natural product simaomicinα has been synthesized. Asymmetric synthesis allowed the assignment of absolute stereochemistry. The enantiomer of the naturally occurring substance shows potent cytotoxicity towards Gram-positive bacteria and human cancer cells. Bn=benzyl, BOM=benzyloxymethyl. |
| doi_str_mv | 10.1002/anie.201304812 |
| format | Article |
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| source | Wiley-Blackwell Journals |
| subjects | Asymmetry Bacteria Cancer Dehydrogenation Human Joining Stereochemistry Synthesis |
| title | Dehydrogenative Coupling to Enable the Enantioselective Total Synthesis of (-)-Simaomicin [alpha] |
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