Dehydrogenative Coupling to Enable the Enantioselective Total Synthesis of (-)-Simaomicin [alpha]

Dehydrogenative Coupling to Enable the Enantioselective Total Synthesis of (-)-Simaomicin [alpha]

The anticancer natural product simaomicinα has been synthesized. Asymmetric synthesis allowed the assignment of absolute stereochemistry. The enantiomer of the naturally occurring substance shows potent cytotoxicity towards Gram-positive bacteria and human cancer cells. Bn=benzyl, BOM=benzyloxymethy...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2013-10, Vol.52 (41), p.10796-10799
Hauptverfasser: Wang, Yizhong, Wang, Chao, Butler, John R, Ready, Joseph M
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetry
Bacteria
Cancer
Dehydrogenation
Human
Joining
Stereochemistry
Synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The anticancer natural product simaomicinα has been synthesized. Asymmetric synthesis allowed the assignment of absolute stereochemistry. The enantiomer of the naturally occurring substance shows potent cytotoxicity towards Gram-positive bacteria and human cancer cells. Bn=benzyl, BOM=benzyloxymethyl.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201304812