Ceria Nanoparticles that can Protect against Ischemic Stroke

Ceria Nanoparticles that can Protect against Ischemic Stroke

Uniform 3 nm‐sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS‐induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-10, Vol.51 (44), p.11039-11043
Hauptverfasser: Kim, Chi Kyung, Kim, Taeho, Choi, In-Young, Soh, Min, Kim, Dohoung, Kim, Young-Ju, Jang, Hyunduk, Yang, Hye-Sung, Kim, Jun Yup, Park, Hong-Kyun, Park, Seung Pyo, Park, Sangseung, Yu, Taekyung, Yoon, Byung-Woo, Lee, Seung-Hoon, Hyeon, Taeghwan
Format: Artikel
Sprache:eng
Schlagworte:
Animals
apoptosis
Biomedical materials
Brain Ischemia - drug therapy
Brain Ischemia - metabolism
Brain Ischemia - prevention & control
Cell death
Cell Death - drug effects
Cell Survival - drug effects
ceria nanoparticles
Cerium - administration & dosage
Cerium - chemistry
Cerium - pharmacology
Cerium oxide
CHO Cells
Cricetinae
Disease Models, Animal
Dose-Response Relationship, Drug
Free Radical Scavengers - administration & dosage
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
In vivo testing
In vivo tests
ischemic stroke
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
Nanoparticles
Rats
reactive oxygen species
Reactive Oxygen Species - metabolism
Scavenging
Stroke - drug therapy
Stroke - metabolism
Stroke - prevention & control
Strokes
therapeutic agents
Tissue Distribution
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Zusammenfassung:Uniform 3 nm‐sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS‐induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201203780