Efficient intracellular delivery and improved biocompatibility of colloidal silver nanoparticles towards intracellular SERS immuno-sensing

High throughput intracellular delivery strategies, electroporation, passive and TATHA2 facilitated diffusion of colloidal silver nanoparticles (AgNPs) are investigated for cellular toxicity and uptake using state-of-art analytical techniques. The TATHA2 facilitated approach efficiently delivered hig...

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Veröffentlicht in:	Analyst (London) 2015-06, Vol.140 (12), p.3929-3934
Hauptverfasser:	Bhardwaj, Vinay, Srinivasan, Supriya, McGoron, Anthony J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - metabolism Biological Transport Biosensing Techniques Colloids Electroporation Immunoassay Intracellular Space - metabolism Nanoparticles Peptides - chemistry Plasmonics Silver Silver - chemistry Silver - metabolism Strategy Toxicity Uptakes
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Beschreibung
Zusammenfassung:	High throughput intracellular delivery strategies, electroporation, passive and TATHA2 facilitated diffusion of colloidal silver nanoparticles (AgNPs) are investigated for cellular toxicity and uptake using state-of-art analytical techniques. The TATHA2 facilitated approach efficiently delivered high payload with no toxicity, pre-requisites for intracellular applications of plasmonic metal nanoparticles (PMNPs) in sensing and therapeutics.
ISSN:	0003-2654 1364-5528
DOI:	10.1039/c5an00435g