Halogen Exchange (Halex) Reaction of 5-Iodo-1,2,3-triazoles: Synthesis and Applications of 5-Fluorotriazoles

A good exchange: 5‐Iodo‐1,2,3‐triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5‐fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3‐triazole compounds.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2012-11, Vol.51 (47), p.11791-11794
Hauptverfasser:	Worrell, Brady T., Hein, Jason E., Fokin, Valery V.
Format:	Artikel
Sprache:	eng
Schlagworte:	click chemistry Exchange Fluorides fluorine Halogens heterocycles Hydrocarbons, Fluorinated - chemical synthesis Hydrocarbons, Fluorinated - chemistry Hydrocarbons, Halogenated - chemistry imaging agents Nucleophiles nucleophilic substitution Substitution reactions Synthesis Triazoles - chemical synthesis Triazoles - chemistry
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Beschreibung
Zusammenfassung:	A good exchange: 5‐Iodo‐1,2,3‐triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5‐fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3‐triazole compounds.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201204979