A Concise and Scalable Strategy for the Total Synthesis of DictyodendrinB Based on Sequential C--H Functionalization

A sequential C--H functionalization strategy for the synthesis of the marine alkaloid dictyodendrinB is reported. Our synthesis begins from commercially available 4-bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram-scale strategy towards the natural product. One by one: A sequential C--H functionalization strategy for the synthesis of the marine alkaloid dictyodendrinB is reported. The synthetic route begins from commercially available 4-bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram-scale strategy towards the natural product.