Iridium-Catalyzed Enantioselective CH Alkylation of Ferrocenes with Alkenes Using Chiral Diene Ligands

The first catalytic and enantioselective CH alkylation of ferrocene derivatives with various alkenes was achieved. A cationic iridium complex, having a chiral diene ligand, and an isoquinolyl moiety as a directing group are essential for regioselective and enantioselective CH bond activation. Director's cut: The first catalytic and enantioselective CH alkylation of ferrocene derivatives with various alkenes was achieved. A cationic iridium complex, having a chiral diene ligand, and an isoquinolyl moiety as a directing group are essential for regioselective and enantioselective CH bond activation. coe=cyclooctene, NaBARF=sodium tetrakis[3,5‐bis(trifluoromethyl)phenyl]borate.