Supramolecular Control of Enzyme Activity through Cucurbit[8]uril-Mediated Dimerization

At the double: Cucurbit[8]uril‐mediated protein dimerization enables reversible control over strong enzyme activation of caspases. Simple addition of a short N‐terminal FGG motif allows for a supramolecular‐mediated 50‐fold enhancement of caspase‐9 catalytic activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2013-03, Vol.52 (10), p.2915-2919
Hauptverfasser:	Dang, Dung T., Nguyen, Hoang D., Merkx, Maarten, Brunsveld, Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Bridged-Ring Compounds - chemistry Bridged-Ring Compounds - pharmacology Catalytic activity cucurbituril Dimerization Enzyme Activation - drug effects Enzyme activity Enzyme Inhibitors - pharmacology Enzymes Imidazoles - chemistry Imidazoles - pharmacology Models, Molecular protein dimerization Proteins Proteins - drug effects reversibility supramolecular chemistry
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Beschreibung
Zusammenfassung:	At the double: Cucurbit[8]uril‐mediated protein dimerization enables reversible control over strong enzyme activation of caspases. Simple addition of a short N‐terminal FGG motif allows for a supramolecular‐mediated 50‐fold enhancement of caspase‐9 catalytic activity.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201208239