8-Aminoquinoline: A Powerful Directing Group in Metal-Catalyzed Direct Functionalization of CH Bonds

8-Aminoquinoline: A Powerful Directing Group in Metal-Catalyzed Direct Functionalization of CH Bonds

Chelate me if you can: Over the last decade, strategies for the functionalization of both C sp 2H and C sp 3H bonds have witnessed an increasing use of a simple, yet powerful directing group, 8‐aminoquinoline (in blue). This auxiliary is very efficient in a wide range of metal‐mediated reactions,...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-09, Vol.52 (38), p.9896-9898
Hauptverfasser: Corbet, Matthieu, De Campo, Floryan
Format: Artikel
Sprache:eng
Schlagworte:
Carboxylic acids
chelates
Chelating
CH activation
Derivatives
heterocycles
palladium
Strategy
synthetic methods
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Beschreibung
Zusammenfassung:Chelate me if you can: Over the last decade, strategies for the functionalization of both C sp 2H and C sp 3H bonds have witnessed an increasing use of a simple, yet powerful directing group, 8‐aminoquinoline (in blue). This auxiliary is very efficient in a wide range of metal‐mediated reactions, and can be readily removed to afford the desired carboxylic acids or corresponding derivatives.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201303556